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1. Curr Opin Microbiol. 2023 Oct 4;76:102394. doi: 10.1016/j.mib.2023.102394. Online ahead of print.
Evolution and synthetic biology.
Ornelas MY(1), Cournoyer JE(1), Bram S(1), Mehta AP(2).
Author information: (1)Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S Matthews Avenue, Urbana, IL 61801, United States. (2)Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S Matthews Avenue, Urbana, IL 61801, United States; Institute for Genomic Biology, University of Illinois at Urbana, Champaign, United States; Cancer Center at Illinois, University of Illinois at Urbana, Champaign, United States. Electronic address:
[email protected].
Evolutionary observations have often served as an inspiration for biological design. Decoding of the central dogma of life at a molecular level and understanding of the cellular biochemistry have been elegantly used to engineer various synthetic biology applications, including building genetic circuits in vitro and in cells, building synthetic translational systems, and metabolic engineering in cells to biosynthesize and even bioproduce complex high-value molecules. Here, we review three broad areas of synthetic biology that are inspired by evolutionary observations: (i) combinatorial approaches toward cell-based biomolecular evolution, (ii) engineering interdependencies to establish microbial consortia, and (iii) synthetic immunology. In each of the areas, we will highlight the evolutionary premise that was central toward designing these platforms. These are only a subset of the examples where evolution and natural phenomena directly or indirectly serve as a powerful source of inspiration in shaping synthetic biology and biotechnology.
Copyright © 2023 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.mib.2023.102394 PMID: 37801925
Conflict of interest statement: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
2. Trends Ecol Evol. 2023 Oct;38(10):910-912. doi: 10.1016/j.tree.2023.07.007. Epub 2023 Aug 14.
Replaying the evolution of multicellularity.
Shalev O(1), Ye X(1), Ratzke C(2).
Author information: (1)Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT), Cluster of Excellence EXC 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, Calwerstrasse 7/1, 72076 Tübingen, Germany. (2)Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT), Cluster of Excellence EXC 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, Calwerstrasse 7/1, 72076 Tübingen, Germany. Electronic address:
[email protected].
The first organisms on Earth were presumably unicellular. At one point, evolution shaped these individual cells into multicellular organisms, which was a significant transition in the history of life on Earth. To investigate how this change happened, Bozdag et al. re-ran evolution in the lab and observed how single-celled yeast forms large multicellular aggregates.
Copyright © 2023 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.tree.2023.07.007 PMID: 37586948 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of interests None declared by authors. Declaration of Generative AI and AI-assisted technologies in the writing process During the preparation of this work the authors used Grammarly in order to check grammar and spelling and improve readability. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.